We achieved sensitive urinary TRPL diagnosis of mice kidney and liver injuries by using simple Eu–DTPA and Eu–DTPA-integrated nanoprobes, respectively, which cannot be realized by traditional blood assays. Notably, TRPL of Eu–DTPA in the enhancer can eliminate the urinary background PL for ultrasensitive detection. Herein, we report a novel urinary time-resolved PL (TRPL) diagnosis strategy by exploiting europium complexes of diethylenetriaminepentaacetic acid (Eu–DTPA) as synthetic biomarkers and designing the activatable nanoprobes. However, it remains a great challenge to achieve sensitive and a specific urinary photoluminescence (PL) diagnosis. Urinary sensing of synthetic biomarkers that are released into urine after specific activation in an in vivo disease environment is an emerging diagnosis strategy to overcome the insensitivity of a previous biomarker assay.
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